Micky van de Ven Double Halts Everton's Run at New Home Ground
Micky van de Ven emerged as the first backline player to net twice in a Premier League game for Tottenham since Jan Vertonghen in spring 2013.
Match summary
The Spurs defender heads home two times in first half
The home side's defender has goal disallowed after video check
Pape Matar Sarr scores final goal in 89th minute
This loss is Everton's initial at Hill Dickinson Stadium
Micky van de Ven scored twice as Tottenham prolonged their winning streak in away games in the Premier League and delivered Everton their first defeat at their new home.
The Toffees were undefeated in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having departed Goodison Park behind after more than a century at the conclusion of last season.
But Spurs captain the Dutchman struck on two occasions from corners in the opening 45 minutes to put their strong form at risk, and they were failed to turn it around before the midfielder - assisted by ex-Everton forward Richarlison - nodded in a third to seal the victory.
Jake O'Brien believed he had levelled the scores a short while after the defender's opener, directing a powerful header past the Spurs keeper from an set-piece.
The Portuguese striker, meanwhile, failed to convert a number of chances, while Vicario made a succession of excellent stops to guarantee the London club went five away games unbeaten in the Premier League.
But the video assistant referee intervened, instructing Craig Pawson to check the goal on the screen and the official ruled that Jack Grealish and Iliman Ndiaye were in an illegal position and had interfered with the Spurs keeper.
The win elevates Thomas Frank's side into third place in the division, five points off north London rivals and leaders Arsenal.
Everton remain 14th and are half a dozen points ahead of the relegation zone.
Spurs breakdown: The defender fulfils role at each end of the field
After a drab weekday display in the Champions League against the French side, where they mustered a mere attempts on goal, Frank chose the French striker up front instead of ex-Everton forward Richarlison.
The new arrival was unable to influence the game before being substituted for the substitute after 60 minutes on the pitch, but it emerged he wasn't needed in the end.
Centre-back the Dutchman transformed into an attacking force to be feared.
Tottenham's first goal came from a cleverly executed set-piece play, with the midfielder directing the ball back across the six-yard box for an unmarked the defender to head home.
And Ven de Ven - filling in as skipper in Cristian Romero's unavailability - added his second in first-half stoppage time as he outjumped the England keeper to head home.
Van de Ven was equally outstanding in defence, combining effectively with his defensive colleague as the duo dealt superbly with the 34 crosses sent their way by the opposition.
Toffees breakdown: Toffees lacking striker's instinct
The club's new home had been a fortress, but it appears the freshness may have faded somewhat and supporters headed to the gates after the midfielder's final goal for Spurs.
The end in the team's unbeaten home run won't be a massive concern for the manager, but their striker situation are.
Beto and the other striker - the Toffees' two recognised centre-forwards - had scored just a single goal between them before the weekend's match.
And they were failed to contribute to that poor tally on a damp and dreary evening on Merseyside.
Beto's form was epitomized when he opted to overhead kick a clear chance from near the goal, despite having room and time to reposition for a more conventional attempt that would have tested the keeper.
The substitute, as well, was unable to make an impact after replacing Beto in the second half.
It wasn't for a lack of opportunity. The majority of the home side's attacks came through the winger and Ndiaye, who tirelessly whipped dangerous crosses into the Spurs penalty area.
What next for both teams?
Everton: The team head to Sunderland in the top flight on early November at 20:00 GMT.
Tottenham: Spurs travel to Newcastle's ground on late October for their fourth-round League Cup match against the Magpies.